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Translation: tomato with beef brisket
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Professor Yu Zhengli, academician of development and administration of China Agricultural University, published on April 3, 2020 in the international top academic journal, gut, the title of "aberrant guts microbiology alters host metabolome and impacts real failure in humans and Rodents, the study explored the relationship among the three groups by analyzing the intestinal microbiome, metabolism and disease phenotype of patients with end-stage renal disease. Furthermore, the establishment of a rodent model of chronic nephropathy was used to verify the mechanism, suggesting that the intestinal flora has a profound impact on the host fecal and serum metabolism groups, especially the intestinal flora is related to the accumulation of uremic toxins and secondary bile acids in patients with end-stage renal disease. It is suggested that intestinal flora may be an important target to reduce uremic toxicity in patients with ESRD.
Article summary
Objective: previous animal studies have shown that the symptoms of uremic toxins in patients with renal failure may be due to the influence of intestinal flora. The aim of this study was to characterize the relationship between the composition of intestinal flora, uremic toxins and symptoms of renal failure in human end-stage renal disease (ESRD).
Experimental design: the intestinal microbiome, serum and fecal metabolism and human phenotype of 223 patients with end-stage renal disease and 69 healthy people (control) were analyzed by multi-dimensional data integration. The relationship between these data sets was revealed, and the effect of intestinal microbiome on toxin accumulation and disease development was verified by animal model of chronic kidney disease.
Results: the composition of intestinal flora in patients with ESRD was closely related to the clinical characteristics of patients, and involved uremic toxin and secondary bile acid synthesis. The relative abundance of microorganisms is related to the serum or fecal concentrations of these metabolites. It was found that the level of serum urotoxin was higher, renal fibrosis was more serious and oxidative stress was more serious in the group of bacteria transplanted from ESRD patients to aseptic mice with renal injury or antibiotic treated rats.
Conclusion: the abnormal intestinal flora in the end-stage patients produces harmful metabolites, which aggravates the clinical prognosis, suggesting that the intestinal flora will be the target to reduce the uremic toxicity of these patients.
Important pictures in the article
Figure 1. Characteristics of serum and fecal microbiome in patients with ESRD are significantly different from those in healthy people
Fig. 2 microbial characteristics and their relationship with changes of metabolites in serum and feces in patients with end-stage disease.
Figure 3. The intestinal microbiome group affects the serum and fecal metabolism groups in patients with end-stage renal disease.
Fig. 4 Changes of intestinal microorganisms in patients with end-stage renal disease lead to the production of uremic toxins and the biosynthesis of secondary bile acids
Fig. 5 animal experiments verify that the flora and two strains (eggerthella lenta and Fusobacterium nucleatum) of end-stage patients can produce uremic toxins and accelerate the development of kidney diseases.
Fig. 6 potential mechanism of ESRD aggravation caused by changes in intestinal microbiome.
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