Professor Chen Fang and Professor Hu Xiaosong, School of food science and nutrition engineering, China Agricultural University, published an article entitled "rejuvenation reductions in high-fat diet fed micro via modifying the structure and metric function of the guide Microbiology" in the international academic journal free radical biology and medicine on April 16, 2020.
Resveratrol (RSV) is a natural polyphenol with anti obesity effect. However, due to its low bioavailability, the mechanism of anti obesity is still unclear. Recent evidence suggests that intestinal flora plays a key role in obesity. The authors hope to study whether the anti obesity effect of RSV is related to the regulation and metabolism of intestinal flora. In this study, the authors found that resveratrol significantly improved the metabolic phenotype of mice induced by high-fat diet (HFD). The characteristics of microbial phylogeny and functional level were analyzed by 16S rRNA sequencing. On the level of phylogeny, resveratrol significantly regulated the composition of intestinal flora in HFD induced mice, which was characterized by an increase in blautia abundance and a decrease in Desulfovibrio and lachnospiraceae pen k4a136 pen group abundance. At the functional level, RSV significantly reduced the pathways related to host metabolic diseases and increased the pathways involved in the production of small molecular metabolites. In addition, fecal bacteria transplantation experiment (FMT) showed similar anti obesity and flora regulation effects as resveratrol. In addition, 4-hydroxyphenylacetic acid (4-HPA) and 3-hydroxyphenylpropionic acid (3-hpp) are two intestinal metabolites of resveratrol, which are helpful to improve lipid metabolism. Finally, the authors concluded that resveratrol mediated improvement of intestinal flora and metabolites could improve the metabolic syndrome induced by HFD in mice. This study revealed that resveratrol is a potential prebiotic, which can improve obesity and metabolic syndrome induced by high-fat diet by affecting intestinal flora. In addition, it is necessary to extend the study to other flavonoids in order to find more evidence to show that intestinal flora is a potential therapeutic target for obesity.
Attached: important pictures in the text
Figure 1 resveratrol reduces body weight and fat accumulation in HFD induced mice
Fig. 2 resveratrol changes the composition of intestinal flora in HFD induced mice
Fig. 3 resveratrol changes intestinal microflora function in HFD induced mice
Fig. 4 fecal bacteria transplantation improved fat accumulation induced by HFD in mice
Fig. 5 fecal bacteria transplantation experiment changed intestinal barrier function and intestinal flora composition of HFD induced mice
Fig. 6 resveratrol changes intestinal microflora metabolites in HFD induced mice
Fig. 7 resveratrol mediated by intestinal flora plays an important role in promoting the production of 3-hpp and 4-HPA
Figure 8 potential mechanism